Aside of all the balancing issues that got added to the list right away I think it would be a good idea to work on improved support for high and widescreen resolutions.
Aside from simply fixing glitches at widescreen resolutions (if that's possible at all) this would include R.P.O.S. scaling and Fontsize selection (if anyone else but me is playing on a TV it's very annoying to have a nonusable UI at high resolutions because the TV is 4 meters away instead of just one meter like a PC Monitor).