You know you're in trouble when Jesus appears in your texture maps

[Alex Mars]

http://www.gameai.com/youknow.html

[Omnituens]

hehe

i noticed 1 name:

Courtesy of Pitspawn (strange name, yes)

o_O

[Lucjan]

You know your game really is in trouble when...you read such lists and are able to recall almost all of these situation from your own experience...

[jernau]

Nice list.

Most apply to more fields than just games or even just software.